Synaptic Basis of Disease

Day 1

Thurs 10th July

Session 1

Molecular Mechanisms 1

08:45

Introductory Remarks: John Isaac & Christian Luscher

09:00

Morgan Sheng 'Regulation of synaptic function by phosphorylation of PSD proteins'

09:30

Jon Hanley 'PICK1-mediated AMPA receptor trafficking'

10:00

Katherine Roche 'Trafficking and phosphorylation of NR2C-containing NMDA receptors'

10:30

Peter Seeburg 'Synaptic AMPA receptor regulation'

COFFEE BREAK

Session 2

Synaptic Mechanisms 1

11:20

Pablo Castillo 'Hippocampal mossy fiber LTP of NMDA receptor transmission'

11:50

Tamas Freund 'Endocannbinoid signaling in hippocampus: involvement in anxiety and epilepsy'

12:20

Roger Nicoll 'NMDA receptors and synapse development'

LUNCH & POSTERS

Session 3

Circuit Mechanisms 1

13:50

Massimo Scanziani 'Rate and timing of dendritic inhibition'

14:20

Carl Petersen 'Synaptic mechanisms of sensory processing in the mouse barrel cortex.'

14:50

Anthony Holtmaat 'Experience-dependent structural plasticity in the mouse somatosensory cortex'

COFFEE BREAK

Session 4 

Synaptic Mechanisms 2

15:40

Christian Luscher 'Cocaine-induced synaptic plasticity'

16:10

Olivier Manzoni 'Use and abuse of cocaine in rats: a neuronal portrait

16:40

Roberto Malinow 'Synaptic function and beta amyloid'

Day 2

 Fri 11th July

Session 5

Synaptic Mechanisms 3

9:00

Christophe Mulle 'Amplification of spike transmission at hippocampal mossy fiber synapses'

9:30

Matthew Frerking 'Subunit-specific localization of kainate receptors on hippocampal interneurons'

10:00

Graham Collingridge 'The role of GSK-3 in synaptic plasticity'

10:30

Dietmar Schmitz  'Role of pH in experimental febrile seizures'

COFFEE BREAK

Session 6

Molecular Mechanisms 2

11:20

Nils Brose 'Genetic dissection of neuroligin function: from synaptogenesis to autism'

11:50

Michael Ehlers 'Structural plasticity with preserved topology in the postsynaptic protein network'

12:20

Suzanne Zukin 'Epigenetic remodeling of AMPA receptor phenotype at synapses of insulted CA1 neurons'

LUNCH & POSTERS

Session 7

Synaptic Mechanisms 4

14:20

Andreas Luthi 'To fear or not to fear: dissecting emotional memory circuits in amygdala'

14:50

Chris Lowry 'Early life experience, stress and serotonergic systems'

15.20

Kaspar Vogt 'Specific GABAergic circuits in the cortex'

COFFEE BREAK

Session 8

Circuit Mechanisms 2

16:10

Karl Diesseroth 'Fast optical interrogation of neural circuitry: development and applications'

16:40

Rosa Cossart 'A top-down description of neuronal networks in living brain slices from the circuit to the synapse level'

Jason Shepherd 'Arc is critical for experience-dependent plasticity in vivo in mouse visual cortex'

Valentina Mercaldo 'Abnormal striatal GABA transmission in the mouse model for the Fragile X Syndrome' 

Sandra Santos 'Effect of the contractin/CASPR complex on AMPA receptor trafficking'

Day 3

  Sat 12. July

Session 9

Molecular Mechanisms 3

8:30

Monica Di Luca 'Novel mechanism of activation of alpha-secretase ADAM10: bridging synaptic failure and the amyloid cascade'

9:00

Isabel Perez-Otano 'Trafficking and sorting of non-conventional NMDARs'

9:30

Daniel Choquet 'A new function for AMPAR mobility in fast synaptic transmission'

10:00

Kimberly Huber 'Altered neocortical synaptic function in the mouse model of Fragile X Syndrome'

COFFEE BREAK

Session 10

Circuit Mechanisms 3

10:50

Chris McBain 'State dependent cAMP sensitivity of feed-forward inhibition in the hippocampal mossy fiber pathway'

11:20

John Isaac 'Synaptic plasticity and the construction of the layer 4 network'

11:50

Bernado Sabatini 'Synapse structural plasticity - a role for autism spectrum disorder proteins?'

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